Botulinum toxin type A (onabotulinumtoxinA or ONA) proved to be a safe and effective treatment for facial lines and wrinkles. Now, AbbVie, the company behind the popular injectable brand, revealed that the treatment has achieved positive topline results for the treatment of platysma prominence, a sign of aging that disrupts the neck, jawline, and lower face.
What is platysma prominence?
According to AbbVie’s press release, platysma prominence refers to the aesthetically unappealing disruption to the neck, jawline and lower face. It is attributed to the contraction of the platysma muscle, a flat, superficial muscle on the lower face and neck. This muscle plays a role in opening or moving your jaw, as well as forming various facial expressions.
Sachin Shridharani, MD, FACS, the lead clinical investigator for the second Phase 3 study, said platysma prominence appears as a part of the natural aging process. Patients with platysma prominence require non-invasive treatment to improve the symmetry between the upper and lower face. He added, “Treatment with a proven neurotoxin may help relax the platysma muscle and thus reduce the appearance of vertical neck bands and improve jawline definition.”
Phase 3 trial and positive results
AbbVie’s Allergan unit recently revealed that the second Phase 3 trial of onabotulinumtoxinA for the treatment of moderate-to-severe platysma prominence met all primary and secondary endpoints. These results were also consistent with the findings from the prior or first Phase 3 trial.
The study involves 426 adults with moderate to severe platysma prominence. Both investigator and subject assessments noted that it achieved its primary endpoint of inducing higher rates of statistically significant improvement in patients compared with placebo (P < .0001).
According to Allergan, they will include the trial data as a part of a US FDA regulatory submission expected near the end of the year. If approved, AbbVie’s onabotulinumtoxinA will be the first and only neurotoxin for plasma prominence.
Giving your neck more TLC at Cutis
The neck is among the first areas of the body to show signs of aging. Apart from having thinner skin, it has less collagen than the face, as well as less natural oil that protects it from dryness and premature thinning. The neck area, furthermore, is constantly exposed to the sun and other environmental aggressors that can contribute to signs of aging.
Non-surgical procedures can help address aging concerns around the neck and chest area. At Cutis, we have:
Microfocused ultrasound with visualization (MFU-V) – is used for naturally lifting and tightening the skin on the face, neck, brow, and under the chin. Using micro-focused ultrasound energy, it heats the skin’s deeper layers and stimulates collagen production. It can:
- Lift and tighten the jawline
- Improve general skin laxity
- Improve fine lines and wrinkles on the upper chest
- Tighten loose skin
Laser skin rejuvenation – uses micro-pulses of laser energy that gently heat the upper dermis. It helps stimulate collagen growth that is beneficial in restoring the health, clarity, and youthfulness of the skin. It can help:
- Reduce the look of lines and wrinkles
- Improve sun damage
- Improve scarring
- Reduce the appearance of enlarged pores
- Improve/treat facial redness and tiny facial veins
Bio-remodelling injectable – can deeply hydrate and remodel the skin. Made of 100% pure hyaluronic acid, it bio-stimulates collagen and elastin to address laxity and other signs of aging. It can help improve sagging and wrinkling on the jowls, neck, and upper chest area. You can turn to it to:
- Boost skin hydration
- Improve the look of lines and wrinkles
- Stimulate tissue repair for acne scarring
- Get a glowing or luminous complexion
- Improve skin firmness
Get in touch with Cutis Medical Laser Clinics in Singapore and schedule a consultation with our aesthetic doctor to learn more about our neck treatments and how we can help you achieve a younger-looking neck area.
Resources:
https://news.abbvie.com/news/press-releases/allergan-aesthetics-announces-positive-topline-results-from-second-phase-3-study-onabotulinumtoxina-botox-cosmetic-for-treatment-platysma-prominence.htm
https://www.fiercepharma.com/pharma/abbvie-cues-botox-another-cosmetic-indication-platysma-prominence
- If you would like to be an informed patient, please contact us at +65-6801-4000 or
cutis@cutislaserclinics.com. - Cutis Medical Laser Clinics, 9 Scotts Road Pacific Plaza, Scotts Medical Center #08-07, Singapore – 228210
+65-6801-4000 - cutis@cutislaserclinics.com
